› 4afl

X-ray diffraction
2.28Å resolution

The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins.

Released:
DOI: 10.2210/pdb4afl/pdb
PDB entry 4afl coloured by chain, front view.
PDB entry 4afl coloured by chain, side view.
PDB entry 4afl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins.
Culurgioni S, Muñoz IG, Moreno A, Palacios A, Villate M, Palmero I, Montoya G, Blanco FJ
J Biol Chem 287 10876-84 (2012)
PMID: 22334692

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inhibitor of growth protein 4 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 104 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UNL4 (Residues: 2-105; Coverage: 42%)
Gene names: ING4, My036
Sequence domains: Inhibitor of growth proteins N-terminal histone-binding
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 30 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C222
Unit cell:
a: 128.45Å b: 186.6Å c: 62.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.256
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

ING1 and ING2: multifaceted tumor suppressor genes.
Guérillon et al. (2013)
3 more

4 mentions without citation

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Ali et al. (2013)
3 more