› 4aib

X-ray diffraction
2.87Å resolution

Crystal Structure of Ornithine Decarboxylase from Entamoeba histolytica.

Released:
DOI: 10.2210/pdb4aib/pdb
PDB entry 4aib coloured by chain, front view.
PDB entry 4aib coloured by chain, side view.
PDB entry 4aib coloured by chain, top view.
Source organism: Entamoeba histolytica HM-1:IMSS
Primary publication:
Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution.
Tapas S, Kumar P, Madhubala R, Tomar S
PLoS One 8 e53397 (2013)
PMID: 23326423

Function and Biology Details

Reaction catalysed: 
L-ornithine = putrescine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ornithine decarboxylase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 395 amino acids
Theoretical weight: 44.57 KDa
Source organism: Entamoeba histolytica HM-1:IMSS
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q58P26 (Residues: 1-395; Coverage: 96%)
Gene names: CL6EHI_100430, ODC
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P212121
Unit cell:
a: 76.671Å b: 119.283Å c: 179.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.253 0.299
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.
Shrivastav et al. (2020)
6 other articles

2 mentions without citation

Polyamines in protozoan pathogens.
Phillips MA. (2018)
1 more