› 4aiw

X-ray diffraction
1.5Å resolution

GAPR-1 with bound inositol hexakisphosphate

Released:
DOI: 10.2210/pdb4aiw/pdb
PDB entry 4aiw coloured by chain, front view.
PDB entry 4aiw coloured by chain, side view.
PDB entry 4aiw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization.
van Galen J, Olrichs NK, Schouten A, Serrano RL, Nolte-'t Hoen EN, Eerland R, Kaloyanova D, Gros P, Helms JB
Biochim Biophys Acta 1818 2175-83 (2012)
PMID: 22560898

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Golgi-associated plant pathogenesis-related protein 1 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9H4G4 (Residues: 1-154; Coverage: 100%)
Gene names: C9orf19, GAPR1, GLIPR2
Sequence domains: Cysteine-rich secretory protein family
Structure domains: CAP

Ligands and Environments

1 bound ligand:
Ligand IHP 1 x IHP
1 modified residue:
Ligand OCS 1 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2221
Unit cell:
a: 44.088Å b: 64.872Å c: 103.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.152 0.187
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

Regulation of Functional Protein Aggregation by Multiple Factors: Implications for the Amyloidogenic Behavior of the CAP Superfamily Proteins.
Sheng et al. (2020)
17 other articles

6 mentions without citation

Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs.
Kelleher et al. (2014)
5 more