› 4ajt

X-ray diffraction
2.5Å resolution

The crystal structure of mouse protein-Z dependent protease inhibitor(mZPI)

Released:
DOI: 10.2210/pdb4ajt/pdb
PDB entry 4ajt coloured by chain, front view.
PDB entry 4ajt coloured by chain, side view.
PDB entry 4ajt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Huang X, Yan Y, Tu Y, Gatti J, Broze GJ, Zhou A, Olson ST
Blood 120 1726-33 (2012)
PMID: 22786881

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185872 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Z-dependent protease inhibitor Chain: A
Molecule details ›
Chain: A
Length: 427 amino acids
Theoretical weight: 49.51 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R121 (Residues: 22-448; Coverage: 100%)
Gene names: Serpina10, Zpi
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3212
Unit cell:
a: 83.53Å b: 83.53Å c: 181.26Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.229 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.
Gettins et al. (2016)
1 more

2 mentions without citation

A Comprehensive Phylogenetic Analysis of the Serpin Superfamily.
Spence et al. (2021)
1 more