› 4akm

X-ray diffraction
2.69Å resolution

Crystal structure of the human lysosome-associated membrane protein LAMP-3 (aka DC-LAMP)

Released:
DOI: 10.2210/pdb4akm/pdb
PDB entry 4akm coloured by chain, front view.
PDB entry 4akm coloured by chain, side view.
PDB entry 4akm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.
Wilke S, Krausze J, Büssow K
BMC Biol 10 62 (2012)
PMID: 22809326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysosome-associated membrane glycoprotein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9UQV4 (Residues: 222-381; Coverage: 41%)
Gene names: DCLAMP, LAMP3, TSC403
Sequence domains: Lysosome-associated membrane glycoprotein (Lamp)
Structure domains: Porin

Ligands and Environments

2 bound ligands:
Ligand IR3 4 x IR3
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P31
Unit cell:
a: 52.6Å b: 52.6Å c: 141.98Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.226 0.249
Expression system: Cricetulus griseus

Quick links

Citations

14 review citations

Scavenger receptors in homeostasis and immunity.
Canton et al. (2013)
13 more

2 mentions without citation

Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.
Wilke et al. (2012)
1 more