› 4aoh

X-ray diffraction
1.04Å resolution

Structural snapshots and functional analysis of human angiogenin variants associated with Amyotrophic Lateral Sclerosis (ALS)

Released:
DOI: 10.2210/pdb4aoh/pdb
PDB entry 4aoh coloured by chain, front view.
PDB entry 4aoh coloured by chain, side view.
PDB entry 4aoh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR
Nat Commun 3 1121 (2012)
PMID: 23047679

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 24-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:
Ligand TAR 1 x TAR
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21212
Unit cell:
a: 85.549Å b: 37.505Å c: 37.512Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.188
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

A census of human RNA-binding proteins.
Gerstberger et al. (2014)
15 more

4 mentions without citation

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Thiyagarajan et al. (2012)
3 more