› 4aqp

X-ray diffraction
2.45Å resolution

The structure of the AXH domain of ataxin-1.

Released:
DOI: 10.2210/pdb4aqp/pdb
PDB entry 4aqp coloured by chain, front view.
PDB entry 4aqp coloured by chain, side view.
PDB entry 4aqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.
de Chiara C, Rees M, Menon RP, Pauwels K, Lawrence C, Konarev PV, Svergun DI, Martin SR, Chen YW, Pastore A
Biophys J 104 1304-13 (2013)
PMID: 23528090

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ataxin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 126 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54253 (Residues: 566-688; Coverage: 15%)
Gene names: ATX1, ATXN1, SCA1
Sequence domains: Ataxin-1 and HBP1 module (AXH)

Ligands and Environments

2 bound ligands:
Ligand NA 3 x NA
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 47.539Å b: 82.699Å c: 137.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.
Kuiper et al. (2017)
1 more

2 mentions without citation

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.
de Chiara et al. (2013)
1 more