› 4axp

Solution NMR

NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.

Released:
DOI: 10.2210/pdb4axp/pdb
PDB entry 4axp coloured by chain, ensemble of 20 models, front view.
PDB entry 4axp coloured by chain, ensemble of 20 models, side view.
PDB entry 4axp coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.
Herbert AP, Riesen M, Bloxam L, Kosmidou E, Wareing BM, Johnson JR, Phelan MM, Pennington SR, Lian LY, Morgan A
PLoS One 7 e41975 (2012)
PMID: 22848679

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
12 kDa heat shock protein Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 11.71 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22943 (Residues: 1-109; Coverage: 100%)
Gene names: GLP1, HOR5, HSP12, YFL014W
Sequence domains: Heat shock protein 9/12
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: NONE
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Many Faces of Amphipathic Helices.
Giménez-Andrés et al. (2018)
10 other articles

1 mention without citation

NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.
Herbert et al. (2012)