› 4ayu

X-ray diffraction
1.5Å resolution

Structure of N-Acetyl-D-Proline bound to serum amyloid P component

Released:
DOI: 10.2210/pdb4ayu/pdb
PDB entry 4ayu coloured by chain, front view.
PDB entry 4ayu coloured by chain, side view.
PDB entry 4ayu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe SE, Jenvey MC, Purvis A, Light ME, Thompson D, Hughes P, Pepys MB, Wood SP
Acta Crystallogr D Biol Crystallogr 70 2232-40 (2014)
PMID: 25084341

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand CA 10 x CA
Ligand N8P 5 x N8P
Ligand NAG 5 x NAG
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 94.42Å b: 70.555Å c: 99.055Å
α: 90° β: 96.9° γ: 90°
R-values:
R R work R free
0.155 0.155 0.168

Quick links

Citations

1 review citation

Sialic acid as a target for the development of novel antiangiogenic strategies.
Chiodelli et al. (2018)
3 other articles

1 mention without citation

Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe et al. (2014)