› 4b4c

X-ray diffraction
1.62Å resolution

Crystal structure of the DNA-binding domain of human CHD1.

Released:
DOI: 10.2210/pdb4b4c/pdb
PDB entry 4b4c coloured by chain, front view.
PDB entry 4b4c coloured by chain, side view.
PDB entry 4b4c coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Allerston CK, Cooper CDO, Shrestha L, Vollmar M, Burgess-Brown N, Yue WW, Carpenter EP, Arrowsmith CH, Edwards A, Bountra C, von Delft F, Gileadi O

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromodomain-helicase-DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14646 (Residues: 1119-1327; Coverage: 12%)
Gene name: CHD1
Sequence domains: CDH1/2 SANT-Helical linker 1
Structure domains: Homeodomain-like

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 4 x EDO
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P41212
Unit cell:
a: 62.464Å b: 62.464Å c: 128.085Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression system: Escherichia coli BL21(DE3)

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