› 4b6v

Solution NMR

The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety

Released:
DOI: 10.2210/pdb4b6v/pdb
PDB entry 4b6v coloured by chain, ensemble of 10 models, front view.
PDB entry 4b6v coloured by chain, ensemble of 10 models, side view.
PDB entry 4b6v coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.
Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KL
Proc Natl Acad Sci U S A 110 3877-82 (2013)
PMID: 23431134

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E type 3 Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 22.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9DBB5 (Residues: 1-207; Coverage: 100%)
Gene name: Eif4e3
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: XPLOR
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

The Organizing Principles of Eukaryotic Ribosome Recruitment.
Pelletier et al. (2019)
12 more

2 mentions without citation

eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.
Osborne et al. (2013)
1 more