4bb2

X-ray diffraction
2.48Å resolution

Crystal structure of cleaved corticosteroid-binding globulin in complex with progesterone

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-139997 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Corticosteroid-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 37.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08185 (Residues: 33-371; Coverage: 89%)
Gene names: CBG, SERPINA6
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Corticosteroid-binding globulin Chain: B
Molecule details ›
Chain: B
Length: 34 amino acids
Theoretical weight: 4.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08185 (Residues: 372-405; Coverage: 9%)
Gene names: CBG, SERPINA6

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2221
Unit cell:
a: 89.19Å b: 122.7Å c: 81.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.177 0.234
Expression system: Escherichia coli BL21(DE3)