› 4bbm

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312

Released:
DOI: 10.2210/pdb4bbm/pdb
PDB entry 4bbm coloured by chain, front view.
PDB entry 4bbm coloured by chain, side view.
PDB entry 4bbm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR
Cell Rep 22 885-894 (2018)
PMID: 29420175

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187747 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase-like 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 38.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92772 (Residues: 1-308; Coverage: 63%)
Gene name: CDKL2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand TC0 2 x TC0
Ligand CL 2 x CL
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P1
Unit cell:
a: 31.583Å b: 68.047Å c: 82.343Å
α: 71.53° β: 89.92° γ: 88.97°
R-values:
R R work R free
0.244 0.243 0.269
Expression system: Spodoptera frugiperda

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Citations

11 review citations

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.
Soares et al. (2019)
10 more