› 4bv6

X-ray diffraction
1.8Å resolution

Refined crystal structure of the human Apoptosis inducing factor

Released:
DOI: 10.2210/pdb4bv6/pdb
PDB entry 4bv6 coloured by chain, front view.
PDB entry 4bv6 coloured by chain, side view.
PDB entry 4bv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor.
Ferreira P, Villanueva R, Martínez-Júlvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M
Biochemistry 53 4204-15 (2014)
PMID: 24914854

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis-inducing factor 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 493 amino acids
Theoretical weight: 53.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95831 (Residues: 121-613; Coverage: 80%)
Gene names: AIF, AIFM1, PDCD8
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FAD 1 x FAD
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 50.9Å b: 90.5Å c: 60.5Å
α: 90° β: 94.6° γ: 90°
R-values:
R R work R free
0.195 0.194 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Respiratory supercomplexes and the functional segmentation of the CoQ pool.
Moreno-Loshuertos et al. (2016)
4 more

6 mentions without citation

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Brosey et al. (2016)
5 more