› 4bvm

X-ray diffraction
0.93Å resolution

The peripheral membrane protein P2 from human myelin at atomic resolution

Released:
DOI: 10.2210/pdb4bvm/pdb
PDB entry 4bvm coloured by chain, front view.
PDB entry 4bvm coloured by chain, side view.
PDB entry 4bvm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.
Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, Kursula P
Acta Crystallogr D Biol Crystallogr 70 165-76 (2014)
PMID: 24419389

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin P2 protein Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02689 (Residues: 1-132; Coverage: 100%)
Gene name: PMP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand PLM 1 x PLM
Ligand VCA 1 x VCA
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P41212
Unit cell:
a: 58.07Å b: 58.07Å c: 101.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.104 0.104 0.121
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Myelination of the nervous system: mechanisms and functions.
Nave et al. (2014)
4 more

8 mentions without citation

Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.
Ruskamo et al. (2014)
7 more