› 4c41

X-ray diffraction
1.8Å resolution

Corticosteroid-binding globulin with engineered disulphide bridge between residues 100 and 236

Released:
DOI: 10.2210/pdb4c41/pdb
PDB entry 4c41 coloured by chain, front view.
PDB entry 4c41 coloured by chain, side view.
PDB entry 4c41 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Towards engineering hormone-binding globulins as drug delivery agents.
Chan WL, Zhou A, Read RJ
PLoS One 9 e113402 (2014)
PMID: 25426859

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticosteroid-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 41.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08185 (Residues: 33-405; Coverage: 97%)
Gene names: CBG, SERPINA6
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 42.13Å b: 73.39Å c: 126.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.206
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

How serpins transport hormones and regulate their release.
Carrell et al. (2017)
2 more

2 mentions without citation

Towards engineering hormone-binding globulins as drug delivery agents.
Chan et al. (2014)
1 more