› 4c49

X-ray diffraction
2.7Å resolution

Reactive loop cleaved human CBG in complex with cortisol

Released:
DOI: 10.2210/pdb4c49/pdb
PDB entry 4c49 coloured by chain, front view.
PDB entry 4c49 coloured by chain, side view.
PDB entry 4c49 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chan WL, Zhou A, Read RJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticosteroid-binding globulin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 373 amino acids
Theoretical weight: 41.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08185 (Residues: 33-405; Coverage: 97%)
Gene names: CBG, SERPINA6
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HCY 4 x HCY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 72.82Å b: 110.42Å c: 92.54Å
α: 90° β: 102.52° γ: 90°
R-values:
R R work R free
0.223 0.22 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links