› 4c7m

X-ray diffraction
2.57Å resolution

The crystal structure of TcpB or BtpA TIR domain

Released:
DOI: 10.2210/pdb4c7m/pdb
PDB entry 4c7m coloured by chain, front view.
PDB entry 4c7m coloured by chain, side view.
PDB entry 4c7m coloured by chain, top view.
Source organism: Brucella melitensis
Primary publication:
Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.
Alaidarous M, Ve T, Casey LW, Valkov E, Ericsson DJ, Ullah MO, Schembri MA, Mansell A, Sweet MJ, Kobe B
J Biol Chem 289 654-68 (2014)
PMID: 24265315

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 134 amino acids
Theoretical weight: 15.06 KDa
Source organism: Brucella melitensis
Expression system: Escherichia coli BL21(DE3)
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 51.966Å b: 73.676Å c: 74.759Å
α: 90° β: 93.29° γ: 90°
R-values:
R R work R free
0.232 0.232 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.
Ve et al. (2015)
13 more

3 mentions without citation

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.
Alaidarous et al. (2014)
2 more