› 4cc3

X-ray diffraction
1.97Å resolution

Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3

Released:
DOI: 10.2210/pdb4cc3/pdb
PDB entry 4cc3 coloured by chain, front view.
PDB entry 4cc3 coloured by chain, side view.
PDB entry 4cc3 coloured by chain, top view.
Source organisms:
Primary publication:
Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading.
Polle L, Rigano LA, Julian R, Ireton K, Schubert WD
Structure 22 304-14 (2014)
PMID: 24332715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169862 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dynamin-binding protein Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 67 amino acids
Theoretical weight: 7.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6XZF7 (Residues: 1513-1577; Coverage: 4%)
Gene names: ARHGEF36, DNMBP, KIAA1010, TUBA
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Protein enabled homolog Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 12 amino acids
Theoretical weight: 1.16 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q03173 (Residues: 547-558; Coverage: 2%)
Gene names: Enah, Mena, Ndpp1

Ligands and Environments

2 bound ligands:
Ligand CL 3 x CL
Ligand PE4 1 x PE4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: R3
Unit cell:
a: 115.87Å b: 115.87Å c: 73.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.215
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

5 review citations

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review.
Dhama et al. (2015)
4 more

1 mention without citation

Municipal wastewater monitoring revealed the predominance of bla GES genes with diverse variants among carbapenemase-producing organisms: high occurrence and persistence of Aeromonas caviae harboring the new bla GES variant bla GES-48.
Tanabe et al. (2023)