› 4cdb

X-ray diffraction
2.15Å resolution

Crystal structure of listeriolysin O

Released:
DOI: 10.2210/pdb4cdb/pdb
PDB entry 4cdb coloured by chain, front view.
PDB entry 4cdb coloured by chain, side view.
PDB entry 4cdb coloured by chain, top view.
Source organism: Listeria monocytogenes
Primary publication:
Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation.
Köster S, van Pee K, Hudel M, Leustik M, Rhinow D, Kühlbrandt W, Chakraborty T, Yildiz Ö
Nat Commun 5 3690 (2014)
PMID: 24751541

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiol-activated cytolysin Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 54.25 KDa
Source organism: Listeria monocytogenes
UniProt:
  • Canonical: A0A0H3GD84 (Residues: 39-526; Coverage: 97%)
Gene name: LMRG_02624
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ACT 4 x ACT
Ligand NA 15 x NA
Ligand TAM 1 x TAM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 26.72Å b: 85.15Å c: 229.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.246

Quick links

Citations

17 review citations

Pore-forming toxins: ancient, but never really out of fashion.
Dal Peraro et al. (2016)
16 more

24 mentions without citation

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.
Christie et al. (2018)
23 more