› 4ci8

X-ray diffraction
2.6Å resolution

Crystal structure of the tandem atypical beta-propeller domain of EML1

Released:
DOI: 10.2210/pdb4ci8/pdb
PDB entry 4ci8 coloured by chain, front view.
PDB entry 4ci8 coloured by chain, side view.
PDB entry 4ci8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.
Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R
Proc Natl Acad Sci U S A 111 5195-200 (2014)
PMID: 24706829

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-126271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Echinoderm microtubule-associated protein-like 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 655 amino acids
Theoretical weight: 72.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00423 (Residues: 167-815; Coverage: 80%)
Gene names: EMAP1, EMAPL, EMAPL1, EML1
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand SO4 25 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 91.98Å b: 83.98Å c: 115.52Å
α: 90° β: 96.61° γ: 90°
R-values:
R R work R free
0.202 0.2 0.251
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine.
Katayama et al. (2015)
18 more

5 mentions without citation

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.
Bayliss et al. (2016)
4 more