› 4cos

X-ray diffraction
1.67Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MYND-type zinc finger-containing chromatin reader ZMYND8 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULU4 (Residues: 83-406; Coverage: 27%)
Gene names: KIAA1125, PRKCBP1, RACK7, ZMYND8
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand DIO 2 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 66.955Å b: 68.835Å c: 70.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.21
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Bromodomain biology and drug discovery.
Zaware et al. (2019)
20 more

5 mentions without citation

Partners in crime: The role of tandem modules in gene transcription.
Sharma et al. (2015)
4 more