Function and Biology Details
Reaction catalysed:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Leucine-tRNA ligase
- Aminoacyl-tRNA synthetase, class Ia
- Rossmann-like alpha/beta/alpha sandwich fold
- Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
- Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
- Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
- Leucyl-tRNA synthetase, editing domain
- Aminoacyl-tRNA synthetase, class I, conserved site
- tRNA
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Leucine--tRNA ligase and RNA (preferred)
PDBe Complex ID:
PDB-CPX-139770 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Leucine--tRNA ligase
Molecule details ›
Chains: A, D
Length: 880 amino acids
Theoretical weight: 99.52 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 880 amino acids
Theoretical weight: 99.52 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P07813 (Residues: 1-860; Coverage: 100%)
Sequence domains:
- tRNA synthetases class I (M)
- Leucyl-tRNA synthetase, editing domain
- tRNA synthetases class I (I, L, M and V)
- Anticodon-binding domain of tRNA ligase
