› 4crh

X-ray diffraction
1.72Å resolution

Crystal structure of the BTB-T1 domain of human SHKBP1

Released:
DOI: 10.2210/pdb4crh/pdb
PDB entry 4crh coloured by chain, front view.
PDB entry 4crh coloured by chain, side view.
PDB entry 4crh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas DM, Sanvitale CE, Bufton JC, Sorrell FJ, Solcan N, Chalk R, Doutch J, Bullock AN
Biochem J 474 3747-3761 (2017)
PMID: 28963344

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3KBP1-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8TBC3 (Residues: 18-120; Coverage: 15%)
Gene names: PP203, SB1, SHKBP1
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P65
Unit cell:
a: 71.29Å b: 71.29Å c: 38.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.164 0.193
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.
Teng et al. (2019)
7 more

4 mentions without citation

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas et al. (2017)
3 more