› 4crs

X-ray diffraction
2.75Å resolution

Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS

Released:
DOI: 10.2210/pdb4crs/pdb
PDB entry 4crs coloured by chain, front view.
PDB entry 4crs coloured by chain, side view.
PDB entry 4crs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mathea S, Elkins JM, Shrestha L, Szklarz M, Tallant C, Newman JA, Cooper CD, Shrestha B, Tumber A, Cocking R, Salah E, von Delft F, Arrowsmith C, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase N2 Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 39.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16513 (Residues: 646-984; Coverage: 35%)
Gene names: PKN2, PRK2, PRKCL2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AGS 1 x AGS
Ligand MG 1 x MG
Ligand SO4 1 x SO4
2 modified residues:
Ligand SEP 1 x SEP
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 68.639Å b: 68.639Å c: 185.473Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.262
Expression system: Spodoptera frugiperda

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