› 4cs7

X-ray diffraction
2.47Å resolution

Crystal structure of the asymmetric human metapneumovirus M2-1 tetramer, form 1

Released:
DOI: 10.2210/pdb4cs7/pdb
Model geometry
Fit model/data
PDB entry 4cs7 coloured by chain, front view.
PDB entry 4cs7 coloured by chain, side view.
PDB entry 4cs7 coloured by chain, top view.
Source organism: Human metapneumovirus
Primary publication:
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae.
Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM
OpenAccess logo Elife 3 e02674 (2014)
PMID: 24842877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein M2-1 Chains: A, B, C, E
Molecule details ›
Chains: A, B, C, E
Length: 189 amino acids
Theoretical weight: 21.43 KDa
Source organism: Human metapneumovirus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8QN58 (Residues: 1-187; Coverage: 100%)
Gene names: M2, M2-1
Sequence domains:
Structure domains: Pneumovirus matrix protein 2 (M2), zinc-binding domain

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 50.15Å b: 92.67Å c: 82.83Å
α: 90° β: 94.48° γ: 90°
R-values:
R R work R free
0.235 0.233 0.262
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

Conformational plasticity of the Ebola virus matrix protein.
Radzimanowski et al. (2014)
6 more

7 mentions without citation

Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes.
Cao et al. (2021)
6 more