› 4cz9

X-ray diffraction
3.5Å resolution

Structure of the sodium proton antiporter PaNhaP from Pyrococcus abyssii at pH 4.

Released:
DOI: 10.2210/pdb4cz9/pdb
PDB entry 4cz9 coloured by chain, front view.
PDB entry 4cz9 coloured by chain, side view.
PDB entry 4cz9 coloured by chain, top view.
Source organism: Pyrococcus abyssi GE5
Primary publication:
Structure and substrate ion binding in the sodium/proton antiporter PaNhaP.
Wöhlert D, Kühlbrandt W, Yildiz O
Elife 3 e03579 (2014)
PMID: 25426802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation/H+ exchanger domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 46.57 KDa
Source organism: Pyrococcus abyssi GE5
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UZ55 (Residues: 1-422; Coverage: 95%)
Gene name: PAB1518
Sequence domains: Sodium/hydrogen exchanger family

Ligands and Environments

1 bound ligand:
Ligand OOC 1 x OOC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P64
Unit cell:
a: 109.566Å b: 109.566Å c: 209.626Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.242 0.242 0.263
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Shared Molecular Mechanisms of Membrane Transporters.
Drew et al. (2016)
9 more

7 mentions without citation

Elevator-type mechanisms of membrane transport.
Garaeva et al. (2020)
6 more