› 4d0o

X-ray diffraction
2.75Å resolution

AKAP13 (AKAP-Lbc) DH domain

Released:
DOI: 10.2210/pdb4d0o/pdb
PDB entry 4d0o coloured by chain, front view.
PDB entry 4d0o coloured by chain, side view.
PDB entry 4d0o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez KR, Knapp S, Fernandes JM, Klussmann E, Elkins JM
Biochem J 464 231-9 (2014)
PMID: 25186459

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A-kinase anchor protein 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 28.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12802 (Residues: 1972-2207; Coverage: 8%)
Gene names: AKAP13, BRX, HT31, LBC
Sequence domains: RhoGEF domain
Structure domains: Dbl homology (DH) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 52.13Å b: 94.84Å c: 109Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.236 0.308
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases.
Smithers et al. (2016)
6 more

1 mention without citation

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez et al. (2014)