› 4d5h

X-ray diffraction
1.75Å resolution

Focal Adhesion Kinase catalytic domain

Released:
DOI: 10.2210/pdb4d5h/pdb
PDB entry 4d5h coloured by chain, front view.
PDB entry 4d5h coloured by chain, side view.
PDB entry 4d5h coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.
Zhou J, Bronowska A, Le Coq J, Lietha D, Gräter F
Biophys J 108 698-705 (2015)
PMID: 25650936

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.73 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00944 (Residues: 411-686; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 9RM 1 x 9RM
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 44.892Å b: 123.587Å c: 50.803Å
α: 90° β: 95° γ: 90°
R-values:
R R work R free
0.183 0.181 0.205
Expression system: Trichoplusia ni

Quick links

Citations

6 review citations

Revisiting Netrin-1: One Who Guides (Axons).
Boyer et al. (2018)
5 more