› 4d7n

X-ray diffraction
1.76Å resolution

TetR(D) in complex with anhydrotetracycline and potassium

Released:
DOI: 10.2210/pdb4d7n/pdb
PDB entry 4d7n coloured by chain, front view.
PDB entry 4d7n coloured by chain, side view.
PDB entry 4d7n coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Tetracycline repressor allostery does not depend on divalent metal recognition.
Werten S, Dalm D, Palm GJ, Grimm CC, Hinrichs W
Biochemistry 53 7990-8 (2014)
PMID: 25432019

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TETRACYCLINE REPRESSOR, CLASS D Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 24.33 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli K-12
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand TDC 1 x TDC
Ligand K 2 x K
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: I4122
Unit cell:
a: 68.065Å b: 68.065Å c: 178.909Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.225
Expression system: Escherichia coli K-12

Quick links

Citations

6 citation in other articles

Modular organisation of inducer recognition and allostery in the tetracycline repressor.
Werten et al. (2016)
5 more