› 4d8o

X-ray diffraction
2.2Å resolution

Crystal Structure of the ankyrin-B ZU5-ZU5-UPA-DD tandem

Released:
DOI: 10.2210/pdb4d8o/pdb
PDB entry 4d8o coloured by chain, front view.
PDB entry 4d8o coloured by chain, side view.
PDB entry 4d8o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function.
Wang C, Yu C, Ye F, Wei Z, Zhang M
Proc Natl Acad Sci U S A 109 4822-7 (2012)
PMID: 22411828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-2 Chain: A
Molecule details ›
Chain: A
Length: 581 amino acids
Theoretical weight: 66.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01484 (Residues: 966-3653; Coverage: 14%)
Gene names: ANK2, ANKB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 75.674Å b: 80.056Å c: 94.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.245
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier.
Nelson et al. (2017)
6 more

6 mentions without citation

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.
Mitchell et al. (2019)
5 more