Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assemblies composition:
PDBe Complex ID:
PDB-CPX-123654 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement factor D
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 24.63 KDa
Source organism: Macaca mulatta
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 228 amino acids
Theoretical weight: 24.63 KDa
Source organism: Macaca mulatta
Expression system: Cricetulus griseus
UniProt:
- Canonical:
F6YBP7 (Residues: 33-260; Coverage: 95%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Ig-like domain-containing protein
Molecule details ›
Chains: D, L
Length: 213 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Structure domains: Immunoglobulins
Length: 213 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q8TCD0 (Residues: 21-238; Coverage: 97%)
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1
Molecule details ›
Chains: E, H
Length: 217 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Length: 217 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P01857 (Residues: 1-102; Coverage: 26%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
