Function and Biology Details
Reactions catalysed:
Converts human Glu-plasminogen to plasmin by cleaving the 560-Arg-|-Val-561 peptide bond that is also hydrolyzed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins.
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Plasminogen activator and Angiostatin (preferred)
PDBe Complex ID:
PDB-CPX-133232 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):