› 4dit

X-ray diffraction
2.6Å resolution

Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor

Released:
DOI: 10.2210/pdb4dit/pdb
PDB entry 4dit coloured by chain, front view.
PDB entry 4dit coloured by chain, side view.
PDB entry 4dit coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kim HT, Lee SC, Chang HJ

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 43.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49841 (Residues: 27-393; Coverage: 87%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0KD 1 x 0KD
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P212121
Unit cell:
a: 70.784Å b: 72.54Å c: 80.663Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.24 0.304
Expression system: Escherichia coli

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