› 4dj2

X-ray diffraction
2.75Å resolution

Unwinding the Differences of the Mammalian PERIOD Clock Proteins from Crystal Structure to Cellular Function

Released:
DOI: 10.2210/pdb4dj2/pdb
PDB entry 4dj2 coloured by chain, front view.
PDB entry 4dj2 coloured by chain, side view.
PDB entry 4dj2 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.
Kucera N, Schmalen I, Hennig S, Öllinger R, Strauss HM, Grudziecki A, Wieczorek C, Kramer A, Wolf E
Proc Natl Acad Sci U S A 109 3311-6 (2012)
PMID: 22331899

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Period circadian protein homolog 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 320 amino acids
Theoretical weight: 35.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35973 (Residues: 191-502; Coverage: 24%)
Gene names: Per, Per1, Rigui
Sequence domains:
Structure domains: PAS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 100.34Å b: 56.87Å c: 100.95Å
α: 90° β: 90.07° γ: 90°
R-values:
R R work R free
0.225 0.208 0.282
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Transcriptional architecture of the mammalian circadian clock.
Takahashi JS. (2017)
17 more

5 mentions without citation

Emerging models for the molecular basis of mammalian circadian timing.
Gustafson et al. (2015)
4 more