› 4dmb

X-ray diffraction
1.9Å resolution

X-ray structure of human hepatitus C virus NS5A-transactivated protein 2 at the resolution 1.9A, Northeast Structural Genomics Consortium (NESG) Target HR6723

Released:
DOI: 10.2210/pdb4dmb/pdb
PDB entry 4dmb coloured by chain, front view.
PDB entry 4dmb coloured by chain, side view.
PDB entry 4dmb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kuzin A, Su M, Seetharaman J, Patel P, Xiao R, Ciccosanti C, Lee D, Everett JK, Acton TB, Montelione GT, Hunt JF, Tong L, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP)

Function and Biology Details

Reaction catalysed: 
A 2'-deoxyribonucleoside 5'-monophosphate + H(2)O = a 2'-deoxyribonucleoside + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-deoxynucleotidase HDDC2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 204 amino acids
Theoretical weight: 23.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7Z4H3 (Residues: 1-204; Coverage: 100%)
Gene names: C6orf74, CGI-130, HDDC2, NS5ATP2
Sequence domains: HD domain
Structure domains: Hypothetical protein af1432

Ligands and Environments

6 bound ligands:
Ligand NO3 3 x NO3
Ligand MG 4 x MG
Ligand GOL 1 x GOL
Ligand PO4 2 x PO4
Ligand PEG 2 x PEG
Ligand UNL 1 x UNL
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P43212
Unit cell:
a: 68.393Å b: 68.393Å c: 174.452Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.207
Expression system: Escherichia coli BL21(DE3)

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