› 4ds0

X-ray diffraction
1.56Å resolution

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

Released:
DOI: 10.2210/pdb4ds0/pdb
PDB entry 4ds0 coloured by chain, front view.
PDB entry 4ds0 coloured by chain, side view.
PDB entry 4ds0 coloured by chain, top view.
Source organism: Rotavirus sp.
Primary publication:
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV
Nature 485 256-9 (2012)
PMID: 22504179

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183098 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Outer capsid protein VP8* Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.57 KDa
Source organism: Rotavirus sp.
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86169 (Residues: 64-224; Coverage: 21%)
Sequence domains: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, FUC, A2G
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 43.75Å b: 35.54Å c: 44.06Å
α: 90° β: 94.85° γ: 90°
R-values:
R R work R free
0.158 0.156 0.187
Expression system: Escherichia coli

Quick links

Citations

58 review citations

Blood Groups in Infection and Host Susceptibility.
Cooling L. (2015)
57 more

3 mentions without citation

Structural Basis of Glycan Recognition of Rotavirus.
Sun et al. (2021)
2 more