› 4dtc

X-ray diffraction
3Å resolution

Crystal Structure of DPP-IV with Compound C5

Released:
DOI: 10.2210/pdb4dtc/pdb
PDB entry 4dtc coloured by chain, front view.
PDB entry 4dtc coloured by chain, side view.
PDB entry 4dtc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xiong B, Zhu LR, Chen DQ, Zhao YL, Jiang F, Shen JK

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 728 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27487 (Residues: 39-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand D5C 2 x D5C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P32
Unit cell:
a: 80.466Å b: 80.466Å c: 290.901Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.206 0.268
Expression system: Homo sapiens

Quick links