› 4dte

X-ray diffraction
1.96Å resolution

Crystal structure of zebrafish plasminogen activator inhibitor-1 (PAI-1)

Released:
DOI: 10.2210/pdb4dte/pdb
PDB entry 4dte coloured by chain, front view.
PDB entry 4dte coloured by chain, side view.
PDB entry 4dte coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Protein conformational change delayed by steric hindrance from an N-linked glycan.
Bager R, Johansen JS, Jensen JK, Stensballe A, Jendroszek A, Buxbom L, Sørensen HP, Andreasen PA
J Mol Biol 425 2867-77 (2013)
PMID: 23702291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 374 amino acids
Theoretical weight: 42.04 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: F1QRB8 (Residues: 19-392; Coverage: 95%)
Gene names: PAI, PAI-1, PAI1, PLANH1, serpine1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 65.16Å b: 73.77Å c: 91.75Å
α: 90° β: 102.73° γ: 90°
R-values:
R R work R free
0.175 0.174 0.219
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz et al. (2014)
1 more

6 mentions without citation

Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
Ambadapadi et al. (2016)
5 more