› 4dvw

X-ray diffraction
2.2Å resolution

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-167

Released:
DOI: 10.2210/pdb4dvw/pdb
PDB entry 4dvw coloured by chain, front view.
PDB entry 4dvw coloured by chain, side view.
PDB entry 4dvw coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site.
Kwon YD, LaLonde JM, Yang Y, Elban MA, Sugawara A, Courter JR, Jones DM, Smith AB, Debnath AK, Kwong PD
PLoS One 9 e85940 (2014)
PMID: 24489681

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 353 amino acids
Theoretical weight: 39.16 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein

Ligands and Environments

3 bound ligands:
Ligand NAG 20 x NAG
Ligand EPE 2 x EPE
Ligand 0M4 2 x 0M4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 64.591Å b: 68.533Å c: 94.155Å
α: 90° β: 91.27° γ: 90°
R-values:
R R work R free
0.187 0.184 0.232
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41.
Lu et al. (2016)
10 more

1 mention without citation

Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site.
Kwon et al. (2014)