› 4dxw

X-ray diffraction
3.05Å resolution

Crystal structure of NavRh, a voltage-gated sodium channel

Released:
DOI: 10.2210/pdb4dxw/pdb
PDB entry 4dxw coloured by chain, front view.
PDB entry 4dxw coloured by chain, side view.
PDB entry 4dxw coloured by chain, top view.
Source organism: alpha proteobacterium HIMB114
Primary publication:
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel.
Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N
Nature 486 130-4 (2012)
PMID: 22678295

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 229 amino acids
Theoretical weight: 26.5 KDa
Source organism: alpha proteobacterium HIMB114
Expression system: Escherichia coli
UniProt:
  • Canonical: D0RMU8 (Residues: 1-228; Coverage: 100%)
Gene name: HIMB114_00013280
Sequence domains: Ion transport protein
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand BNG 4 x BNG
Ligand CA 2 x CA
Ligand PX4 1 x PX4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P42
Unit cell:
a: 163.437Å b: 163.437Å c: 61.071Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.268
Expression system: Escherichia coli

Quick links

Citations

72 review citations

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
71 more

45 mentions without citation

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
44 more