› 4dzv

X-ray diffraction
2.1Å resolution

Complex of 4-alpha/beta bound to gp41-5

Released:
DOI: 10.2210/pdb4dzv/pdb
PDB entry 4dzv coloured by chain, front view.
PDB entry 4dzv coloured by chain, side view.
PDB entry 4dzv coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array.
Johnson LM, Mortenson DE, Yun HG, Horne WS, Ketas TJ, Lu M, Moore JP, Gellman SH
J Am Chem Soc 134 7317-20 (2012)
PMID: 22524614

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164414 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
gp41-5 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.25 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
4-alpha/beta Chain: B
Molecule details ›
Chain: B
Length: 39 amino acids
Theoretical weight: 4.94 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
2 modified residues:
Ligand HMR 6 x HMR
Ligand B3E 5 x B3E

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 47.95Å b: 57.302Å c: 102.036Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

Inhibition of α-helix-mediated protein-protein interactions using designed molecules.
Azzarito et al. (2013)
5 more

3 mentions without citation

Unnatural helical peptidic foldamers as protein segment mimics.
Sang et al. (2023)
2 more