› 4e08

X-ray diffraction
2Å resolution

Crystal structure of Drosophila melanogaster DJ-1beta

Released:
DOI: 10.2210/pdb4e08/pdb
PDB entry 4e08 coloured by chain, front view.
PDB entry 4e08 coloured by chain, side view.
PDB entry 4e08 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1.
Lin J, Prahlad J, Wilson MA
Biochemistry 51 3799-807 (2012)
PMID: 22515803

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194201 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein dj-1beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 19.55 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VA37 (Residues: 1-187; Coverage: 100%)
Gene names: CG1349, dj-1-beta, dj-1beta
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P3221
Unit cell:
a: 52.52Å b: 52.52Å c: 227.173Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.193 0.246
Expression system: Escherichia coli

Quick links

Citations

2 review citations

DJ-1 in Parkinson's Disease: Clinical Insights and Therapeutic Perspectives.
Repici et al. (2019)
1 more

5 mentions without citation

Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification.
Ghosh et al. (2016)
4 more