› 4e0q

X-ray diffraction
2.5Å resolution

Crystal structure of MPN domain from COP9 signalosome

Released:
DOI: 10.2210/pdb4e0q/pdb
PDB entry 4e0q coloured by chain, front view.
PDB entry 4e0q coloured by chain, side view.
PDB entry 4e0q coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.
Zhang H, Gao ZQ, Wang WJ, Liu GF, Shtykova EV, Xu JH, Li LF, Su XD, Dong YH
FEBS Lett 586 1147-53 (2012)
PMID: 22575649

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 141 amino acids
Theoretical weight: 16.44 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VCY3 (Residues: 51-187; Coverage: 40%)
Gene names: CG6932, CSN6
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 109.062Å b: 109.062Å c: 46.437Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.261
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The translational factor eIF3f: the ambivalent eIF3 subunit.
Marchione et al. (2013)
2 more

3 mentions without citation

Architecture of human translation initiation factor 3.
Querol-Audi et al. (2013)
2 more