› 4e40

X-ray diffraction
1.6Å resolution

The haptoglobin-hemoglobin receptor of Trypanosoma congolense

Released:
DOI: 10.2210/pdb4e40/pdb
PDB entry 4e40 coloured by chain, front view.
PDB entry 4e40 coloured by chain, side view.
PDB entry 4e40 coloured by chain, top view.
Source organism: Trypanosoma congolense IL3000
Primary publication:
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Higgins MK, Tkachenko O, Brown A, Reed J, Raper J, Carrington M
Proc Natl Acad Sci U S A 110 1905-10 (2013)
PMID: 23319650

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-124130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative uncharacterized protein Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 26.85 KDa
Source organism: Trypanosoma congolense IL3000
Expression system: Escherichia coli
UniProt:
  • Canonical: G0UVW6 (Residues: 114-365; Coverage: 65%)
Gene name: TCIL3000_10_2930
Sequence domains: Haptoglobin-hemoglobin receptor
Structure domains: Ferritin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6522
Unit cell:
a: 104.53Å b: 104.53Å c: 113.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.223
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The molecular arms race between African trypanosomes and humans.
Pays et al. (2014)
10 more

6 mentions without citation

Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Higgins et al. (2013)
5 more