› 4e48

X-ray diffraction
2.5Å resolution

Structure of 20mer double-helical RNA composed of CUG/CUG-repeats

Released:
DOI: 10.2210/pdb4e48/pdb
PDB entry 4e48 coloured by chain, front view.
PDB entry 4e48 coloured by chain, side view.
PDB entry 4e48 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structural dynamics of double-helical RNAs composed of CUG/CUG- and CUG/CGG-repeats.
Tamjar J, Katorcha E, Popov A, Malinina L
J Biomol Struct Dyn 30 505-23 (2012)
PMID: 22731704

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196792 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 20 nucleotides
Theoretical weight: 6.34 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand K 2 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P321
Unit cell:
a: 43.642Å b: 43.642Å c: 158.556Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.203 0.279
Expression system: Not provided

Quick links

Citations

5 review citations

RNA Structures as Mediators of Neurological Diseases and as Drug Targets.
Bernat et al. (2015)
4 more

4 mentions without citation

Structural studies of CNG repeats.
Kiliszek et al. (2014)
3 more