› 4e71

X-ray diffraction
2.26Å resolution

Crystal structure of the RHO GTPASE binding domain of Plexin B2

Released:
DOI: 10.2210/pdb4e71/pdb
PDB entry 4e71 coloured by chain, front view.
PDB entry 4e71 coloured by chain, side view.
PDB entry 4e71 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guan X, Wang H, Tempel W, Tong Y, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-B2 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15031 (Residues: 1452-1562; Coverage: 6%)
Gene names: KIAA0315, PLXNB2
Sequence domains: Plexin cytoplasmic RhoGTPase-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P6522
Unit cell:
a: 48.38Å b: 48.38Å c: 157.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.244 0.285
Expression system: Escherichia coli BL21

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