› 4eax

X-ray diffraction
2.3Å resolution

Mouse NGF in complex with Lyso-PS

Released:
DOI: 10.2210/pdb4eax/pdb
PDB entry 4eax coloured by chain, front view.
PDB entry 4eax coloured by chain, side view.
PDB entry 4eax coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional insights into lipid-bound nerve growth factors.
Tong Q, Wang F, Zhou HZ, Sun HL, Song H, Shu YY, Gong Y, Zhang WT, Cai TX, Yang FQ, Tang J, Jiang T
FASEB J 26 3811-21 (2012)
PMID: 22649032

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-nerve growth factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 120 amino acids
Theoretical weight: 13.49 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01139 (Residues: 122-241; Coverage: 54%)
Gene names: Ngf, Ngfb
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand S12 2 x S12
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U, SPRING-8 BEAMLINE BL41XU
Spacegroup: R3
Unit cell:
a: 96.529Å b: 96.529Å c: 163.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.219 0.259

Quick links

Citations

1 review citation

Neurotrophins in the Neuropathophysiology, Course, and Complications of Obstructive Sleep Apnea-A Narrative Review.
Gabryelska et al. (2023)
5 other articles

7 mentions without citation

Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step.
Weiskirchen R. (2015)
6 more