› 4ec7

X-ray diffraction
2.6Å resolution

Cobra NGF in complex with lipid

Released:
DOI: 10.2210/pdb4ec7/pdb
PDB entry 4ec7 coloured by chain, front view.
PDB entry 4ec7 coloured by chain, side view.
PDB entry 4ec7 coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Structural and functional insights into lipid-bound nerve growth factors.
Tong Q, Wang F, Zhou HZ, Sun HL, Song H, Shu YY, Gong Y, Zhang WT, Cai TX, Yang FQ, Tang J, Jiang T
FASEB J 26 3811-21 (2012)
PMID: 22649032

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Venom nerve growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 13.08 KDa
Source organism: Naja atra
UniProt:
  • Canonical: P61898 (Residues: 1-116; Coverage: 100%)
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand L44 1 x L44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P622
Unit cell:
a: 118.12Å b: 118.12Å c: 87.35Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.228 0.269

Quick links

Citations

1 review citation

Neurotrophins in the Neuropathophysiology, Course, and Complications of Obstructive Sleep Apnea-A Narrative Review.
Gabryelska et al. (2023)
6 other articles

4 mentions without citation

Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Paoletti et al. (2021)
3 more