› 4eda

X-ray diffraction
2.7Å resolution

Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses

Released:
DOI: 10.2210/pdb4eda/pdb
Model geometry
Fit model/data
PDB entry 4eda coloured by chain, front view.
PDB entry 4eda coloured by chain, side view.
PDB entry 4eda coloured by chain, top view.
Source organism: Influenza A virus (A/Korea/01/2009(H1N1))
Primary publication:
Insight into structural diversity of influenza virus haemagglutinin.
Cho KJ, Lee JH, Hong KW, Kim SH, Park Y, Lee JY, Kang S, Kim S, Yang JH, Kim EK, Seok JH, Unzai S, Park SY, Saelens X, Kim CJ, Lee JY, Kang C, Oh HB, Chung MS, Kim KH
J Gen Virol 94 1712-1722 (2013)
PMID: 23636824

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111522 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin Chains: A, C
Molecule details ›
Chains: A, C
Length: 336 amino acids
Theoretical weight: 37.34 KDa
Source organism: Influenza A virus (A/Korea/01/2009(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C5MQE6 (Residues: 18-344; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 182 amino acids
Theoretical weight: 20.84 KDa
Source organism: Influenza A virus (A/Korea/01/2009(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C5MQE6 (Residues: 345-520; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P6
Unit cell:
a: 208.126Å b: 208.126Å c: 65.765Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.237 0.289
Expression system: Trichoplusia ni

Quick links

Citations

3 review citations

Investigational hemagglutinin-targeted influenza virus inhibitors.
Zeng et al. (2017)
2 more

6 mentions without citation

Monomeric Intermediates Formed by Vesiculovirus Glycoprotein during Its Low-pH-induced Structural Transition.
Abou-Hamdan et al. (2018)
5 more